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The most common side effects in the retatrutide group were gastrointestinal symptoms, which were dose-dependent and mostly mild to moderate in severity

That pattern is common and normal not a sign of failure

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149 Reducing the number of harmful Firmicutes bacteria while increasing the number of Bacteroidetes helps to restore intestinal homeostasis and improve intestinal permeability

Fatigue accompanies both tirzepatide use and urinary tract infections
