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This shift happens because semaglutide activates GLP-1 receptors in your hypothalamus, the brain region controlling hunger and satiety

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This activates multiple signaling pathways including protein kinase A/signal transducer and activator of transcription, phosphoinositide 3-kinases/protein kinase B, mitogen-activated protein kinase, and nuclear factor kappa B, and may exert anti-inflammatory effects in the liver and beyond