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Semaglutide can sometimes worsen symptoms of acid reflux or GERD because it slows stomach emptying

Nausea is a common early side effect that usually resolves within 13 weeks as your body adjusts

Potential evening downsides The biggest risk with evening dosing is forgetting

This is a well-known side effect of naltrexone plus bupropion, and it is contraindicated in patients with uncontrolled hypertension 54
