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The following comparison table features the prescription and OTC medications in this article

Patients with Cardiovascular Risk Factors: Research suggests that GLP1 receptor agonists may provide cardiovascular benefits, including reduced risk of heart attack and stroke in patients with type 2 diabetes

Adding orlistat when already consuming less fat may provide minimal additional benefit, while still carrying orlistat's digestive side effects

Exendin-4 demonstrated the ability to bind to the same receptors as human GLP-1, producing similar glucose-lowering effects, but with a significantly longer duration of action

1 Individual trials vary: REWIND dulaglutide reported stroke HR 0.76 , while SUSTAIN-6 semaglutide reported nonfatal stroke HR 0.61