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It should also not be used by people who have had bariatric surgery

For example, if a patient is managing hypertension and diabetes, their clinician can adjust their weight management plan considering how GLP-1s may affect blood pressure medication and how it can improve their A1C levels

For instance, exenatide has been shown to ameliorate endothelial dysfunction induced by hyperglycemia and hyperlipidemia through direct activation of eNOS via the AMP-activated protein kinase (AMPK) pathway [113]

J Obes Metab syndrome (2021) 30(1):129

For example, certain FTO variants are associated with greater hunger sensation posttreatment, while MC4R variants may relate to leptin sensitivity restoration