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STEP 1 Trial Results (Published in New England Journal of Medicine, 2021): 1,961 adults with obesity or overweight with weight-related health conditions 68-week treatment period Semaglutide 2.4mg weekly injection + lifestyle intervention Average weight loss: 14.9% of total body weight (compared to 2.4% with placebo) 50.5% of participants lost 15% of body weight 32.0% of participants lost 20% of body weight STEP 2 Trial (Adults with Type 2 Diabetes): Demonstrated 9.6% average weight loss in patients with diabetes Also showed improvements in glycemic control (HbA1c reduction) STEP 3 Trial (Intensive Behavioral Therapy Component): Combined semaglutide with intensive behavioral therapy Average weight loss: 16.0% of total body weight Important context about clinical data: These trials studied FDA-approved brand-name semaglutide at specific doses with structured lifestyle interventions including dietary counseling, exercise recommendations, and behavioral support

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