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There have been concerns that GLP-1RAs may increase the risk of intestinal obstruction

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Patients on pemvidutide experienced only 21.9% of weight loss attributable to lean mass

### Funding Statement SDL and AC were supported by the National Science Foundation (Grant Nos.\ CAREER DMS-1944574 and DMS-2325258) ### Author Declarations I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained

Sequences containing NEP-24.11 cleavage sites were filtered out to enhance stability