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As the body of literature on this topic expands, more refined clinical guidance for the use of GLP-1RAs is expected to emerge

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37 Similarly, in a retrospective cohort study of 3435 people with type 2 diabetes exposed to tirzepatide for 180 days and over compared with a matched unexposed cohort, tirzepatide was associated with an increased risk of new-onset proliferative diabetic retinopathy primarily in those with pre-existing nonproliferative diabetic retinopathy

However, it is important to interpret these findings cautiously, as: Research suggests that weight loss outcomes may be influenced by dosage: Balancing effectiveness and tolerability remains a key focus of ongoing studies