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The Guasch-Ferre cohort analysis suggests that replacing less healthy fats with olive oil is consistently associated with less weight gain over time

It allows Novo to defend its semaglutide franchise while broadening access to patients who prefer oral therapy

It is not widely prescribed

The hazard ratios for the full follow-up period in these analyses was 1.37 (95% confidence interval 0.84 to 2.23), 1.04 (0.69 to 1.57), and 0.99 (0.67 to 1.46), respectively

The study design of these studies primarily aims at demonstrating non-inferiority (safety) of a novel substance compared to a control arm with standard of care excluding the novel drug