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13,14 There was no significant difference in MACE in patients with or without prior CVD, whereas the secondary endpoints of heart failure, worsening of renal disease and all-cause mortality were between 9% and 17% lower in those receiving GLP-1 analogue therapy

Through the end of safety follow-up in each trial, 0.6% of adults in each of the tirzepatide and placebo groups reported suicidal ideation, with most of these reports deemed low risk

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GI side effects most common during this phase Months 4-12: Maintenance dose reached