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However, semaglutide is not a suitable first-line drug for diabetes that has not been controlled by diet and exercise

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These well-documented properties make it an exceptionally valuable asset in advanced studies focused on insulin resistance models, hepatic lipid metabolism, and the complex mechanisms of energy regulation

while glycaemic efficacy diminishes at lower eGFR levels, some agents are licensed for heart failure and chronic kidney disease at eGFRs below 30 ml/min/1.73m

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