does your body make glp 1 GLP-1 Genetics: How Genes Affect Appetite, Semaglutide, and Tirzepatide Response Primer: The Skinny on GLP-1s

Kamel-Abusalha L et al

The FDA approved Trulicity in 2014 to treat Type 2 diabetes in conjunction with diet and exercise

However, no therapeutic drugs have been able to meet all the required criteria, especially when it comes to improving fibrosis

This is particularly noteworthy because two competing oral small-molecule GLP-1 programs from Pfizer, lotiglipron (discontinued in 2023) and danuglipron (discontinued in April 2025), were terminated due to liver toxicity concerns

There are approved GLP-1 and GIP/GLP-1 medications available for specific indications, and there are investigational multi-receptor agonists still being studied