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Results Most patients notice reduced appetite within the first few weeks

Kabirdev Mandavya: employee of Novo Nordisk A/S

Sudden, significant swelling in one leg that is painful, red, or warm to the touch can indicate deep vein thrombosis and requires urgent evaluation

This side effect typically feels strongest in the morning or when consuming fatty or large meals, and usually subsides within two to four weeks as your digestive system adapts

While correlative data such as these cannot establish causality, the observation that women are also more likely than men to discontinue these medications strengthens the interpretation that the efficacy-to-tolerability ratio for these drugs is lower for women (Fig