glp 1 a1c lowering Glucagon-like peptide-1 receptor: mechanisms and advances in therapy GLP-1 single, dual, and triple
Description
The Lancet Diabetes & Endocrinology , 10(1), 45-57
Sean Wharton, an internal medical physician in Toronto
One explanation for this appears to be a negative-feedback inhibition of L-cell secretion by the elevated levels of active GLP-1 brought about by DPP-IV inhibition (47), an effect which may be mediated by a paracrine action of somatostatin secreted from neighboring D-cells in the gut (97, 98)
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