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Semaglutide is a GLP-1 receptor agonist medication that helps with weight loss by decreasing appetite

In this case, 5-h-fasted mice were intraperitoneally administered with 0.75 U of insulin (Sigma-Aldrich, MO, USA) per kg body weight, and blood glucose concentrations were determined before (0) and at 15, 30, 60, and 120 min after insulin injection

Conversely, participants who were given a placebo (only diet and exercise) showed an average weight reduction between 0.2 and 3.0 kg

While the exact mechanism isn't fully understood, headaches likely result from dehydration due to gastrointestinal side effects, blood glucose fluctuations, or metabolic changes during treatment initiation

Clinical trials show that Lixisenatide is well-tolerated and can help overweight people lose weight