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Description
If you experience any combination of these symptoms after taking tirzepatide, call Poison Control (1-800-222-1222) or seek emergency care without delay
Post-meal nausea usually peaks within the first week of treatment or dose increase and subsides within 4-6 weeks as your digestive system adapts

And they should be

Among 618 obese or overweight patients who took other medications, only three had NAION

Ahmad E, Lim S, Lamptey R, et al