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Therefore, more participants and longer follow-up time may better reflect the relationship between the use of GLP-1RAs and the risk of respiratory disease

The American journal of clinical nutrition

doi: 10.1038/s41514-022-00084-z

Classic examples include native GLP-1, which has a plasma half-life of approximately 2 minutes and required continuous infusion in early studiesan impractical route for chronic therapyyet was subsequently transformed into a once-weekly therapeutic through lipidation and albumin-binding strategies ( Third, pleiotropic signaling that aligns with physiological function rather than nonspecific toxicity favors re-evaluation