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Despite having minimal effects on body weight, treatment with -MSTN/-ActA alone also showed beneficial shifts in the lean/fat body composition in obese mice as previously shown in non-obese mice, NHPs, and humans (Fig

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Two main forms of the A protein have been identified: A40 and A42, which contain 40 and 42 amino acid residues respectively ( FIGURE 1 Several studies have confirmed that GLP-1R reduces A production and deposition

While SGLT2i primarily reduce preload and afterload through natriuresis and osmotic diuresis, GLP-1 RAs exert anti-inflammatory and metabolic remodeling effects, together potentially providing synergistic cardiovascular protection

The respective affinities of GIP(1-42) and GLP-1(7-36) as determined by radioligand binding were 200 pM and 700 pM, consistent with the literature (51, 52)