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They are secreted mainly in the stomach and the main effect was thought to increase insulin secretion from the pancreatic beta cell in response to glucose given by mouth (but not by intravenous since it bypasses the stomach)
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The dual GLP-1/GIP receptor agonist DA4-JC shows superior protective properties compared to the GLP-1 analogue liraglutide in the APP/PS1 mouse model of alzheimers disease

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Rights and permissions About this article Cite this article Drucker, D.J., Rosen, C.F
