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Potential Side Effects and Considerations Common side effects of weight loss medications include gastrointestinal symptoms such as nausea, which occurs in about 44% of users, and general symptoms like headache and fatigue

Some medications may require special handling or temperature control during shipping

Some particles may be peptide aggregates

The reduced caloric intake, combined with metabolic adaptation, can produce feelings of low energy during the first several weeks at each new dose level

Percentage of body weight lost at 72 weeks in the 15 mg tirzepatide group was 22.6% for those with disease duration of 10 years or less, 22.9% with 10 to 20 years duration, and 22.1% for more than 20 years disease duration