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These genetic alterations are involved in the regulation of lipid metabolism and insulin sensitivity (240)

Patients with higher-sensitivity genetic profiles often require lower doses, while those with lower sensitivity may benefit from faster escalation or higher therapeutic doses

Those starting with higher body fat should expect initial fat loss with muscle preservation, transitioning to muscle gain as body composition improves

Third, GLP1s influence on gut microbiota and the gutbrain axis may also play a role, given the emerging evidence tying gut health to mental health

You just want to lose enough weight to feel good in those jeans and, ultimately, good about yourself