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Supplementary information Acknowledgements We acknowledge the contributions of the clinical staff of the Intramural Research Program of the National Institute on Drug Abuse, and the Clinical Research Unit of Johns Hopkins Bayview Medical Center, as well as the University of Maryland, Baltimore, a member of the Graduate Partnership Program, National Institutes of Health (NIH)

It mimics GLP-1, a natural hormone involved in appetite regulation, digestion, insulin release and fullness

This model of personalized weight loss care ensures that every patient receives dynamic, responsive adjustments based on their real-time needscritical factors for safe and sustainable success with GLP-1 weight loss medication

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In total, 98.4% patients completed the trial, and the vital status was known at the end of the trial for 99.5%