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At that stage, telling someone to just eat whole foods resembles telling someone with tinnitus to enjoy the silence. Therefore, ultra-processed foods contribute to the problem, but they do not explain it entirely

Patients with a mean age of 61 years and a diabetes duration of 15 years were randomized to receive oral semaglutide 3, 7, or 14 mg or placebo [44]
Nakamura et al, 2016)

Lancet (2016) 388(10053):1659724
