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16 To ensure that the severity of DR did not confound the study results for the preexisting DR subgroup, we did a look-back on individuals with vs without GLP-1 RA prescriptions to assess the number of individuals with varying severity of DR at baseline

Publication bias was evaluated using funnel plots for RCTs that provided data on the primary outcome, as shown in Supplemental Fig

Samuel Seidu: methodology, data curation, formal investigation, writingreview and editing

Abbreviations GLP-1RA Glucagon-Like Peptide-1 Receptor Agonists SGLT2 Sodiumglucose cotransporter 2 DPP4 Dipeptidyl Peptidase-4 T2D Type 2 diabetes AF/Aflutter Atrial fibrillation or flutter TSH Thyroid-stimulating hormone MPR Medication possession ratio PS Propensity score IPCW Inverse probability censoring weight SMD Standardized mean differences Author contributions TJ and NMSO conceived and designed the study

In those combinations, the risk of hypoglycemia increases with any incretin therapy