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GLP-1Rs were expressed in five of six skin biopsies from psoriasis plaques, in one of six biopsies from unaffected psoriatic skin, and in one of six biopsies from healthy skin

As proof of concept, bariatric surgery has been associated with a decreased prevalence of obesity-related cancers, including PDAC, illustrating the key role of weight management for cancer prevention 3,4

Accordingly, despite losing 25% of their body mass, GLP-1MK-801-treated mice maintained an energy expenditure that was similar to that of vehicle-treated control mice and was therefore also significantly higher than the gradually decreasing energy expenditure observed in mice that were calorie-restricted to match the weight loss trajectory of GLP-1MK-801-treated mice