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Greater insulinotropic action of oral glucose relative to its peripheral administration was demonstrated for both normal weight and obese individuals [63] and henceforth became known as the incretin effect [64,65]
Many research planning windows are shorter 12 to 24 weeks is common for tolerability and titration assessment, with longer cycles for efficacy endpoints
However, given the few conflicting findings (like the 2014 case report), it is prudent to approach each patient individually
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[PubMed] [Google Scholar] 35.Therneau T, Lumley T
