is tirzepatide safer than semaglutide vs. Semaglutide: What You Should Know Semaglutide vs. Tirzepatide for weight

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These include: Increased appetite and food cravings , which may work against Wegovy's appetite-suppressing effects Insulin resistance and elevated blood glucose levels , potentially leading to steroid-induced diabetes Fluid retention and weight gain , particularly in the face, neck, and trunk (cushingoid features) Redistribution of body fat to central areas Muscle wasting , which can reduce metabolic rate Patients taking both medications may experience reduced weight loss efficacy compared to those taking Wegovy alone, though the appetite-suppressing effects of Wegovy may help mitigate steroid-induced hunger

That puts pressure on Novo and Lilly to engage physicians around maintenance dosing and longer-term patient retention strategies

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