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The effects were more pronounced in patients with higher BMI, and attenuated in those with lower BMI. The associations observed in the main analysis were similar in sensitivity analyses restricting urgent HF visits in the FLOW trial to adults requiring IV therapy and when investigator-reported events of hospitalization and urgent visits due to HF were used instead of adjudicated events

Retatrutide timing introduces additional complexity because retatrutide activates three receptors (GLP-1, GIP, and glucagon)

Janzen KM, Steuber TD, Nisly SA

* Increases satiety, reducing food intake and promoting weight loss

This particular adverse reaction has attracted the attention of regulators 44