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Initial investigations into the cardiovascular safety effects of glucose-lowering medications in patients with T2D revealed an unexpected reduction in CV complications and mortality with the use glucagon-like peptide 1 receptor agonists (GLP1-RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2is)

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We also found that the FXR-antagonistic BAs, including TMCA, HDCA or UDCA, antagonized the effect of CDCA, a potent FXR agonist, on the Shp mRNA expression and GLP-1 secretion in NCI-H716 cells (Fig