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For efficient knockdown of the TGF- and DPP4 genes, pooled siRNAs (siRNA1 and siRNA2) targeting each gene were used

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23 Given the speed of divergence of the curves, it is unlikely that the pleiotropic effects of GLP-1 RAs, including reduction of SBP (by 2 to 3 mm Hg) and low-density lipoprotein cholesterol (by 0.1 to 0.2 mmol/L), along with significant weight loss, 28 would be responsible for the benefit

Advise women to inform their healthcare provider if they are pregnant or intend to become pregnant

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