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Need for Improved Safety and Tolerability All GLP-1 receptor agonists have the potential to cause GI adverse effects, but it has been suggested that nausea attenuates more rapidly with long-acting GLP-1 receptor agonists than short-acting agents because of their less pronounced effects on gastric emptying (16)

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Targeting the incretin/glucagon system with agonists Figure 1: Schematic representation of the effects of multi-agonists targeting the receptors for GLP-1/Glucagon, GLP-1/GIP and GLP-1/GIP/Glucagon [28] In Part I of our blog we reported on dual receptor agonists targeting the incretin/glucagon system to treat obesity and type 2 diabetes mellitus with high efficacy

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Gastrointestinal adverse events with GLP-1 receptor agonists for obesity: a systematic review

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Insulin resistance increases

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