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5 Conclusion DM as a major challenge in global public health, is showing a serious trend of increasing prevalence year by year

Patients can try taking their medication with food or starting with a lower dose and gradually increasing it at the discretion of their prescriber

However, semaglutide's liver effects are largely indirect, mediated through weight loss and improved metabolic parameters rather than direct hepatic lipid oxidation

GLP-1 receptor agonists have demonstrated glycaemic control, cardiovascular benefits in certain patient populations and significant weight reduction effects

[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Gromada J., Franklin I., Wollheim C.B