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Several prior recommendations have been renewed including treatment of hypertension (Class of Recommendation 1), treatment of atrial fibrillation (Class of Recommendation 2a), use of ARBs (Class of Recommendation 2b), and avoidance of routine use of nitrates or phosphodiesterase-5 inhibitors (Class of Recommendation 3: No Benefit)
In cases of diabetes, long-term use is often necessary unless significant remission is achieved through sustained weight loss and lifestyle change
To manage metformin-induced diarrhea, start with a low dose, take the medication with food, consider extended-release formulations, stay hydrated, adjust your diet, and consult a healthcare professional if needed
