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Metabolic Adaptation Is Not a Major Barrier to Weight-Loss Maintenance

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IBX will continue to cover GLP-1 drugs for other FDA-approved clinical indications to treat medical conditions, such as diabetes and cardiovascular disease

However, recent insights suggest that the gut and brain GLP-1 systems operate largely independently with mRNA transcripts for proglucagon (GCG), the precursor peptide for GLP-1, being abundant in the brainstem, particularly within the nucleus tractus solitarius (NTS

25 Although trials comparing the efficacy of tirzepatide and other GLP-1 are still underway, recent studies have demonstrated encouraging outcomes
