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Keywords: glucagon-like peptide-1 receptor agonists, substance-related disorders, braingut axis, alcoholism, tobacco use disorder, cocaine-related disorders, amphetamine-related disorders, opioid-related disorders, bloodbrain barrier, translational research, biomedical 1

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Discussion This is the preclinical study investigating the utility of [ 18 F]FB(ePEG12)12-exendin-4, a novel PEGylated exendin-4-based probe, in PET/CT imaging for detecting insulinoma using both INS-1 xenograft mouse models and Pdx1-Cre;Trp53 R172H ;Rb f/f mice, a novel multiple panNEN mouse model, with developed endogenous insulinoma and glucagonoma

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