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Proper dosing schedules become essential because higher doses lead to more frequent side effects such as gastrointestinal upset, and the side effects can be managed by using the minimum effective dose or slow titration (Figure 2)

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Conversely, the chronic exposure to the GLP-1RA Exendin-4 (Ex4) reduced the hypothalamic expression of the kisspetptin-1 (Kiss-1) receptors, with a marked reduction of the preovulatory LH peak and a delayed puberty onset [35]

Tendulkar P, Kant R, Rana S, Yadav P, Mirza AA, Agarwal D (2022) Efficacy of pro-kinetic agents in type 2 diabetes mellitus patients with gastroparesis using lactulose hydrogen breath testing: a randomized trial