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Hims & Hers and its surrogates objected

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Coffee, particularly the morning cup, stimulates colonic contractions through multiple mechanisms

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[DOI] [PubMed] [Google Scholar] Besterman HS, Cook GC, Sarson DL, Christofides ND, Bryant MG, Gregor M, Bloom SR

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The fix: When escalating to a new dose, consider temporarily shifting to evening injection for 1 to 2 weeks

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The potential mechanisms underlying the increased risk of gastric aspiration are not fully understood, and nowadays it is explained mainly by delayed gastric emptying and inhibition of gastrointestinal motor function that GLP-1-RAs exert through both central motor nuclei and vagal afferents [13, 14]

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