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3.3 Weight management and body composition optimization: foundational effect for reproductive benefit Across the diverse landscape of evidence involving various comparators and time windows, weight loss and improvements in body composition emerge as the most consistent and clinically interpretable benefit findings of GLP-1RAs in PCOS, particularly within obesity- and IR-dominant phenotypes

10.2147/JPR.S219684 [DOI] [PMC free article] [PubMed] [Google Scholar] Evans S

The primary analysis population included all randomly assigned patients, using on-treatment data collected before initiation of rescue medication

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Pharmacokinetic profiles were fit to a two-compartment model (SC depot and systemic compartment)