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Description
Functional mapping and expression data indicate the presence of GLP-1Rs in the central amygdala (CeA), hippocampus, and PFC, which are implicated in affective modulation of craving and top-down executive control [33]

When subcutaneous adipose tissue loses its capacity to safely store excess energy, lipid spillover toward the liver increases, promoting hepatic steatosis

OJO: El GLP-1 retrasa el vaciado gstrico y reduce la motilidad intestinal
Economically, the potential impact of GLP-1 medications on obesity management is profound (Risk Strategies Insights, 2020) The direct and indirect costs associated with obesityincluding healthcare expenditures, loss of productivity, and the psychological burdenare substantial
By reducing the expression of pro-inflammatory cytokines and activating anti-inflammatory signaling, GLP-1RA-based therapies may mitigate the inflammatory processes that sustain neuropathic pain [66,67,68]