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Some doctors are trying to reduce the negative effects of this by titrating off the medications (giving a lower dose for a period of time to help ease the transition), but ultimately it boils down to this

Patients with a history of pancreatitis should be especially cautious about any alcohol consumption while on GLP-1 medications

I keep seeing this study being posted - the important point being that the patients in this study were all diabetics and the comparison was between those on GLP1 or on SGLT2i drugs

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While preclinical studies, primarily in animal models 17,18 , suggest a potential beneficial effect of GLP-1 RAs on mood and behavior, the clinical evidence in humans remains unclear 19,20