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GLP-1 receptors are also abundantly expressed in areas of the central nervous system involved in appetite regulation, including the hypothalamus and brainstem

While preliminary studies and observational signals suggest potential thyroidal effects, no RCTs have evaluated progression of Hashimoto thyroiditis or Graves disease under GLP-1RA therapy [32,58]

You might feel pressure to reach the maximum dose quickly, but studies show that patients who take 20-24 weeks to reach their optimal dose have better long-term success rates than those who escalate doses rapidly

Patients receiving tirzepatide also had lower risks of cardiovascular outcomes like myocardial infarction, heart failure and heart failure exacerbations

Statistical modeling was used to analyze the association between GLP-1 exposure and breast cancer incidence