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By hitting both pathways at once, tirzepatide produces a more powerful and synergistic effect on appetite suppression and metabolic regulation
The administered active compound is Shanzhiside methylester, utilized in Wistar rats for allodynia testing at concentrations of 10, 30, 100, and 300 g intrathecally, functioning as a GLP-1 receptor agonist [11]
No, GLP-1 receptor agonists are not specifically contraindicated in Crohn's disease, but caution is advised in patients with active or severe gastrointestinal disease
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