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the mean treatment difference was statistically significantly greater with IcoSema vs semaglutide (ETD 1.07 [95% CI 1.37, 0.76] mmol/l

How Tirzepatide Affects Your Digestive System Tirzepatide works by mimicking incretin hormones that control appetite and blood sugar

Non-digestive symptoms like headaches, dizziness or tiredness can occur, but are more common if you're not eating or drinking enough while taking Mounjaro

Hypoglycaemia risk is generally low with this combination, as neither metformin nor Wegovy typically causes low blood sugar when used without other glucose-lowering medications

Tesamorelin preferentially reduces visceral fat without significantly affecting subcutaneous fat