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Common side effects (10% incidence) observed in trials included injection-site reactions (redness, pain), headache, diarrhea, and fatigue [pubmed.ncbi.nlm.nih.gov]
Discuss options with a clinician to match benefits and tolerability to your goals
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To date, over 150 pathogenic variants have been identified in the MC4R gene, including missense, nonsense, and frameshift mutations
Meta-analysis data shows retatrutide producing approximately 38% greater weight loss than tirzepatide (16.34 kg versus 11.82 kg)
