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Recently, Eli Lilly introduced a promising new oral GLP-1 receptor agonist called orforglipron, which has significantly piqued my professional curiosity.
Observing rs-fMRI, the functional brain connectivity in GLP-1R KO mice was significantly lower than that in the WT group (p=0.0032 for gFCD, p=0.0002 for whole-brain correlation, p<0.0001 for ALFF)
There are now even more options available for patients who may be candidates for GLP-1 therapy
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