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Lancet Lond Engl 394:121130 Frias JP, Nauck MA, Van J, Benson C, Bray R, Cui X, Milicevic Z, Urva S, Haupt A, Robins DA (2020) Efficacy and tolerability of tirzepatide, a dual glucose-dependent insulinotropic peptide and glucagon-like peptide-1 receptor agonist in patients with type 2 diabetes: A 12-week, randomized, double-blind, placebo-controlled study to evaluate different dose-escalation regimens

Dysregulated insulin, cortisol, thyroid hormones, and leptin can also make it difficult to lose visceral fat

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In addition, when comparing populations with and without T2DM, the incidence rate of PD in the T2DM cohort was 1.32 times higher than in the non-DM cohort [46]