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In the STEP 1 trial (published in the New England Journal of Medicine), participants using Wegovy lost an average of 14.9% of their body weight over 68 weeks approximately 35 lbs from a starting weight of 232 lbs

Moreover, the anatomy of the PPG-neuron projections is ideally situated to provide interoceptive information from the hindbrain to the limbic areas mediating the responses to stress (111, 112)

These observations receive support of our mutagenesis studies by measuring both cAMP responses and receptor binding affinities (Fig