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Description
Wegovy and Zepbound use weekly injections, which many patients find simpler and easier to sustain over long treatment windows for adherence benefits

Participants either self-administered semaglutide (GLP-1RA), tirzepatide (dual GLP-1/GIP RA), or were included in a control group with no relevant medication

Collectively, these results indicate that the inhibition of intestinal FXR signaling by non-12-OH FXR-antagonistic BAs is critically involved in the regulation of GLP-1 production, insulin secretion, and glucose homeostasis by T3

View Our Interactive Dashboard on GLP-1RA Therapies in Development (Free Excel Available) Lilly, Hanmi work on triple agonists

Zepbound is FDA-approved for use in conjunction with a reduced-calorie diet and increased physical activity for obesity
