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[DOI] [PubMed] [Google Scholar] 18.Reasner C, Olansky L, Seck TL, et al

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Retatrutide (LY3437943) represents a major advance in this direction as a synthetic peptide designed to simultaneously activate GLP-1R, GIPR, and GCGR [2,3]

If you fall into any of these buckets, microdosing is unlikely to solve the underlying problem: BMI over 35 with obesity-related conditions (Type 2 diabetes, hypertension, sleep apnea, PCOS) History of bariatric surgery with significant weight regain Plateaued at a microdose for more than 4 to 6 months with no meaningful progress Have tried microdosing twice or more and stopped both times Need to lose more than 50 pounds to reach a healthy weight At BodEvolve Bariatric & Cosmetic Surgery Center, dr Frenzel works with patients across Texas who came in thinking a GLP-1 microdose would be the answer, and left with a clearer plan that actually matched their goals