glp-1 agonist adverse effects What are the side of agonists? Clinical Focus on GLP-1 Agonists

A Swedish national study has shown that girls in the obese cohort have a 43% higher risk of anxiety and depression compared to girls in the general population (adjusted HR: 1.43, 95% CI: 1.311.57

However, it still has a high sugar content and glycemic impact, which makes it less suitable for GLP-1 users looking for blood sugar-friendly alternatives

On a cellular level, the polarization of macrophages has been stimulated by this molecule, shifting them from the inflammatory M1 phenotype to the anti-inflammatory M2 phenotype, which plays a vital role in tissue regeneration as well in reducing inflammation, as they produce cytokines like IL-10 and TGF-[5]

It only means that the FDA wants more definitive long-term data

In fact, long-term trials that aim to evaluate the efficacy of GLP-1 RAs in reducing liver fibrosis are not currently available